European Advanced Postgraduate Course in Classical and Molecular Cytogenetics 2020

European Advanced Postgraduate Course in Classical and Molecular Cytogenetics

Director: Professor Jean-Michel Dupont, Paris - France


This course was started by Professor Jean Paul Bureau 23 years ago and has been held in Nîmes under his directorship ever since. It is designed to provide advanced training in constitutional, haematological, and oncological cytogenetics to medical graduates, pharmacists, pathologists, biologists, health professionals and researchers, with an academic qualification. The students will be trained to identify genetic abnormalities for diagnosis and prognosis, and for fundamental and applied research using both classical and molecular cytogenetic techniques. The course is co-organized by E.C.A. and two French Universities, either as a Diploma (Basic = only the lectures or Advanced = lectures + practical training) or as a stand-alone course (lectures only).


Practical Information


A ten-day course held in February/March of each year. Venue: Faculty of Medicine, Nîmes, France.
Venue: Faculty of Medicine, Nîmes, France.
Official language: English.

Practical training (only for students registered for the advanced Diploma)

A training of maximum 2 months in a cytogenetic laboratory. A list of laboratories is provided during the theoretical course.


The assessment for the basic diploma will be on the basis fo a one-hour examination held at the end of the lecture course. The knowledge of the students for the advanced diploma will be assessed in september by a written test (three questions) and an oral examination including a presentation (10-15 min) related to the practical training. The University will award a diploma to only those students who have passed. All participants (including those for the stand-alone course) will receive a certificate of attendance by the E.C.A.



A special price is available for participants in the 4* Vatel Hotel close to the course venue. We highly recommend that all participants stay in this hotel where all the lecturers will be hosted in order to promote interactions during the course.
Accommodation is included in the stand-alone course fee.


Registration opens in September and closes on January 30th. To register please send a letter of application together with your CV by e-mail to one of the organizers mentioned below. If you are accepted you will receive a registration form.

Prof. Jean-Michel DUPONT
Laboratoire de Cytogénétique
Hôpital Cochin
27 rue du Fbg St Jacques
75014 Paris, FRANCE
e-mail: [email protected]
[email protected]
Laboratoire de Biologie Cellulaire
et Cytogénétique Moléculaire
Faculté de Médecine Montpellier-Nîmes,
Avenue Kennedy, 30900 Nîmes, FRANCE

Registration Fees

Diploma: From €360 to €1734 depending on the status of the student. Accommodation NOT included. Stand-alone course: €1300 (E.C.A. members) or €1400 (Non E.C.A. members); accommodation included on a shared double room basis. Extra fee for a single room on request.

2020 Course provisional program
March 16 to March 25, 2020

This approximately 55 hours theoretical part of the course attempts to cover the field of cytogenetics in the broadest sense. Thetopics can be divided into the following categories:

Technical aspects:

Classical Cytogenetics:

Cell culture techniques; Chromosome staining methods (Q-, G-, C-, R- banding and high resolutionbanding);

Molecular Cytogenetics:

Methods and principles of Fluorescence In Situ Hybridization (FISH) and MFISH; Array CGH; Application of Massively Parallel Sequencing to Cytogenetics; Production and use of molecular probes; Databaseuse in Cytogenetics;

Laboratory quality assessment.

Clinical cytogenetics:


Frequency of chromosome disorders; Cell cycle, mitosis and meiosis, gametogenesis; Heterochromatic and euchromatic variants; Numerical chromosome abnormalities; Structural abnormalities: translocations, inversions, insertions, deletions, rings, markers; Risk assessment for balanced abnormalities; X inactivation; numerical and structural abnormalities of the X and the Y; Mosaicism; Chimaeras; ISCN 2016.


Phenotype of common autosomal and gonosomal aneuploidies; Chromosome abnormalities in recurrent abortions; Cytogenetics and infertility; Microdeletion syndromes; Uniparental disomy and its consequences; Genomic imprinting; Genetic counselling and ethical issues in cytogenetics.

Prenatal diagnosis:

Indications, methods and interpretation; Risk assessment for chromosomal abnormalities; Non-invasive methods using foetal nucleic acids and foetal cells in maternal blood; Pre-implantation diagnosis.

Cancer Cytogenetics:

Molecular approach to cancer cytogenetics; Predisposition to cancer, Chromosome instability syndromes; Chromosomemutagenesis; Solid tumors; Clinical applicationin onco-haematology.


Genome architecture; Structure of chromatin; Structure of metaphase chromosomes, Mechanisms of chromosome abberations; Origin of aneuploidy; Evolution and plasticity of the human genome; Animal cytogenetics; Plant cytogenetics.

The students will have the opportunity to evaluate the course.

The European Cytogeneticists Association offers two fellowships for the European Advanced Postgraduate Course in Classical and Molecular Cytogenetics to candidates of excellence. The Education Committee of the E.C.A. will select the suitable candidates.

The scholarship includes registration to the course and accommodation in Vatel Hotel in a shared double room but does not include travel costs nor Universitiy registration.
Scholarships will not be allocated to students whos eregistration is paid by a third party institution.